abstract：:The ability of erythrocytes to synthesize porphyrins from delta-aminolaevulic acid was compared in healthy people, patients with true iron-deficiency anaemia, and anaemic patients with rheumatoid arthritis. Porphyrin synthesis was found to be impaired in true iron deficiency but not in rheumatoid arthritis cases showi...

journal_title：Journal of clinical pathology

authors： Gutniak O,Kopéc M,Nieczaj J

更新日期：1971-05-01 00:00:00

abstract：:The morphology of the labial salivary glands in subjects with and without cystic fibrosis has been studied by light and electron microscopy. The terms ;light' cell, ;dark' cell, ;clear' cell, and ;myoepithelial' cell are used to describe the four cell types distinguished at the level of the electron microscope. The da...

journal_title：Journal of clinical pathology

authors： Doggett RG,Bentinck B,Harrison GM

更新日期：1971-04-01 00:00:00

abstract：:In all cases of primary endocardial fibroelastosis investigated diffuse degenerative changes in the ganglion cells were detected. Thickened endocardium was formed by the proliferation of mesenchymal cells located under the endothelial endocardium and of the mesenchyme surrounding the necrobiotic muscle cells. In some ...

journal_title：Journal of clinical pathology

authors： Zóltowska A

更新日期：1971-04-01 00:00:00

abstract：:A patient with megaloblastic anaemia due to nutritional folate deficiency is described. Partial villous atrophy and malabsorption of xylose showed progressive improvement to normal with folic acid therapy. ...

journal_title：Journal of clinical pathology

authors： Dawson DW

更新日期：1971-03-01 00:00:00

abstract：:The routine estimation of large numbers of serum folic acid and vitamin B(12) levels using the Baird and Tatlock(1) Analmatic clinical system is described and the method evaluated.Precision, accuracy, and carryover are shown to be at acceptable levels, and the advantages and disadvantages of the use of the system are ...

journal_title：Journal of clinical pathology

authors： Colvin G,Gibson GL,Neill DW

更新日期：1971-02-01 00:00:00

abstract：:An ultramicro electrophoretic technique for the separation of serum lipoproteins is described using agarose gel on microscope slides.The interaction between the agarose gel and lipoproteins has been reduced and the separation between beta- and pre-beta-lipoproteins has been improved over existing methods. A semiquanti...

journal_title：Journal of clinical pathology

authors： Elphick MC

更新日期：1971-02-01 00:00:00

abstract：:In 12 normal subjects plasma calcium and phosphorus concentrations were estimated during a normal working day. In the individual subjects fluctuations from the fasting values occurred during the period of study, but at no time during that period did the mean values differ significantly from the fasting plasma calcium ...

journal_title：Journal of clinical pathology

authors： Wills MR

更新日期：1970-12-01 00:00:00

abstract：:In the present investigation, the prevalence of focal lymphocytic adenitis in the submandibular salivary gland was observed in a series of 116 postmortem subjects after suitable exclusions had been made. Focal lymphocytic adenitis could not be demonstrated in the labial salivary glands. The degree of lymphocytic infil...

journal_title：Journal of clinical pathology

authors： Chisholm DM,Waterhouse JP,Mason DK

更新日期：1970-11-01 00:00:00

abstract：:A case of florid rheumatoid heart disease with complete heart block is described, and the histopathology of the atrioventricular conducting tissue is described in detail. ...

journal_title：Journal of clinical pathology

authors： Harris M

更新日期：1970-10-01 00:00:00

abstract：:Structural chromosomal aberrations, in the form of breaks, were found in a significantly higher proportion of bone marrow cells in patients with infective hepatitis than in controls. These anomalies were observed during the first and third weeks after the onset of jaundice but had subsided by the sixth week. Chromosom...

journal_title：Journal of clinical pathology

authors： Matsaniotis N,Kiossoglou K,Maounis F,Anagnostakis D

更新日期：1970-10-01 00:00:00

abstract：:Agar gel, cellulose acetate, and starch gel electrophoresis are all capable of diagnosing sickle-cell anaemia, sickle-cell haemoglobin C disease, and haemoglobin C disease in cord blood samples. Of these three electrophoretic techniques, agar gel is the easiest to interpret.Paper electrophoresis can reliably and rapid...

journal_title：Journal of clinical pathology

authors： Yaswon GI,Huntsman RG,Metters JS

更新日期：1970-09-01 00:00:00

abstract：:A radial immunodiffusion technique has been used to measure levels of four serum proteins in preeclampsia with or without proteinuria and in normal pregnant and non-pregnant controls. In preeclampsia unaccompanied by proteinuria, albumin and transferrin levels are similar to those found in the normal pregnant controls...

journal_title：Journal of clinical pathology

authors： Horne CH,Howie PW,Goudie RB

更新日期：1970-09-01 00:00:00

abstract：:An investigation into the noise levels in a clinical chemistry laboratory has been carried out. It was shown that although the levels were insufficient to cause damage to hearing, they exceeded the criteria of acceptability for offices and workshops. ...

journal_title：Journal of clinical pathology

authors： Griffiths PD,Kell RL,Taylor W

更新日期：1970-07-01 00:00:00

abstract：:The apparent volumes of distribution of Evans blue and (59)Fe-dextran were determined in 18 studies.(59)Fe-dextran volume was 5% lower than Evans blue volume, a highly significant difference. The rate of loss of (59)Fe dextran from the circulation was significantly less than that of Evans blue. ...

journal_title：Journal of clinical pathology

authors： Wilson RJ,Mills IH

更新日期：1970-05-01 00:00:00

abstract：:A method is described for the separation and determination of individual bile acids in serum and in intestinal contents, employing thin-layer chromatography and fluorimetry. The mean recovery from intestinal juice was 94% and from serum 82%. Normal values for the individual bile acids of serum and examples of clinical...

journal_title：Journal of clinical pathology

authors： Panveliwalla D,Lewis B,Wootton ID,Tabaqchali S

更新日期：1970-05-01 00:00:00

abstract：:A study has been made of 523 strains of staphylococci on the basis of biological properties, phage typing, and serology. The value of serology in the identification of pathogenic staphylococci has been assessed. ...

journal_title：Journal of clinical pathology

authors： Choudhuri KK,Chakrabarty AN

更新日期：1970-05-01 00:00:00

abstract：:An immunological method for detecting fibrin degradation products by tanned cells agglutination has been standardized. The effects of different variables, such as cell concentration, pH, and length of incubation, and the specificity of the reaction, are described. The method is compared with other immunological techni...

journal_title：Journal of clinical pathology

authors： Das PC

更新日期：1970-05-01 00:00:00

abstract：:The detection of lymphoid cells by routine examination of the urine after renal allotransplantation has proved to be a useful early indication of rejection. In a study of 36 rejection episodes, 20 (56%) were associated with a significant number of lymphocytes in the urine. The incidence was much higher when rejection ...

journal_title：Journal of clinical pathology

authors： Papadimitriou M,Chisholm GD,Kulatilake AE,Shackman R

更新日期：1970-03-01 00:00:00

abstract：:This is a retrospective study of the results of 4,642 blood cultures taken from 2,190 patients from 1960 to 1967 in one London hospital. The results suggested that an increased incidence of bacteraemias at this particular hospital was mainly due to the increase in the number of patients having blood cultures. Some of ...

journal_title：Journal of clinical pathology

authors： Crowley N

更新日期：1970-03-01 00:00:00

abstract：:The Fisher Hem-Alyzer is a multitest sequential discrete analyser with automatic printout of digitized results on paper tape. The instrument is well designed, soundly constructed, and reliable in routine use. Cross contamination from the sampler probe or between the cuvettes is minimal. Accuracy and precision are both...

journal_title：Journal of clinical pathology

authors： Lappin TR,Lamont A,Nelson MG

更新日期：1970-02-01 00:00:00

abstract：:A technique is described for obtaining samples of bladder epithelium using soluble swabs. Changes indicating neoplasia were seen in a large proportion of patients with bladder carcinoma. These changes were absent in the non-neoplastic control cases. The method provided tissue similar to that obtained by biopsy and sur...

journal_title：Journal of clinical pathology

authors： Trott PA,Williams G,Attridge PW

更新日期：1969-11-01 00:00:00

abstract：:Haemoglobin, haematocrit, and plasma iron values were estimated on blood samples collected from 100 male and 113 female National Blood Transfusion Service blood donors, and from 83 male and 66 female age-matched control subjects. No significant differences in any of these values were found to exist between the donors ...

journal_title：Journal of clinical pathology

authors： French EA,Sitlani PK

更新日期：1969-11-01 00:00:00

abstract：:Toxoplasmosis is an infection, congenital or acquired, caused by Toxoplasma gondii. A pilot study using toxoplasmin skin antigen was undertaken to establish the incidence of the infection in the London area as a preliminary to a larger study of the effects of the infection upon pregnancy, the foetus, and the newborn i...

journal_title：Journal of clinical pathology

authors： Ruoss CF,Bourne GL

更新日期：1969-11-01 00:00:00

abstract：:A method is described of measuring the response of human lymphocytes to phytohaemagglutinin stimulation using iododeoxyuridine labelled with the gamma-emitting isotope (125)I. The results indicate useful clinical applications. ...

journal_title：Journal of clinical pathology

authors： Craig AW,Garrett JV,Jackson SM

更新日期：1969-09-01 00:00:00

abstract：:Michaëlsson's (1961) method for the measurement of plasma bilirubin concentration was found to be complicated by conjugated bilirubin. Delaying the addition of the accelerator, diphylline, corrected this fault. The method was calibrated using serum or plasma, since reconstituted protein solutions introduced large erro...

journal_title：Journal of clinical pathology

authors： Thompson RP

更新日期：1969-07-01 00:00:00

abstract：:Urine specimens were collected from 26 normal subjects, 10 patients with proven primary hyperparathyroidism, and eight patients with hypercalcaemia due to other causes. After overnight urine concentration, an oral water load was given to induce a diuresis and provide urine specimens with a relatively wide range of cre...

journal_title：Journal of clinical pathology

authors： Wills MR

更新日期：1969-05-01 00:00:00

abstract：:The serotype of 320 strains of Proteus mirabilis from clinical material was determined. Using 20 O antisera and four H antisera 61% of strains could be fully identified and 90% partially identified. A large number of serotypes were recognized but no difference was found between the serotype of organisms infecting the ...

journal_title：Journal of clinical pathology

authors： De Louvois J

更新日期：1969-05-01 00:00:00

abstract：:A case of combined squamous and intestinal metaplasia of the renal pelvis, associated with hydronephrosis, chronic pyelonephritis, and lithiasis, is reported. The changes are considered to be due primarily to mechanical irritation of the pelvic epithelium. ...

journal_title：Journal of clinical pathology

authors： Salm R

更新日期：1969-03-01 00:00:00

abstract：:Experience after 18 months' work with the SMA-4 system of multiple analysis for routine haematology is described, as well as the modifications to the machine which have been made for smoother operation. ...

journal_title：Journal of clinical pathology

authors： Green AE,Middleton VL,Prentis KG,Signy AG

更新日期：1969-01-01 00:00:00

abstract：:In a study of a group of 325 blood donors between the ages of 18 and 65 years, the total leucocyte and polymorph counts of the females aged 50 to 65 years were found to be significantly lower than those of the corresponding group of male donors. In the whole series of female donors, there were significantly lower tota...

journal_title：Journal of clinical pathology

authors： Allan RN,Alexander MK

更新日期：1968-11-01 00:00:00

abstract：:The results of using a product of serum thyroxine and triiodothyronine binding coefficient, estimated by simple methods, to give a ;free thyroxine index' in normal women, in pregnant women, and in patients taking oral contraceptives is described. The method is believed to provide a reliable means of assessing thyroid ...

journal_title：Journal of clinical pathology

authors： Gimlette TM,Piffanelli A

更新日期：1968-11-01 00:00:00

abstract：:A method is described for the estimation of serum free fatty acids based on the ultramicro method of Novák. The difficulty of obtaining an accurate standard graph has been overcome and the interfering effects of phospholipids have been reduced. The method is simple to perform and gives accurate, precise results in 50 ...

journal_title：Journal of clinical pathology

authors： Elphick MC

更新日期：1968-09-01 00:00:00

abstract：:A labial biopsy technique is described and was used to study 40 patients with connective tissue disease and 60 postmortem subjects. More than one focus of lymphocytes per 4 sq mm of minor salivary tissue was found to be a consistent finding in patients with Sjögren's disease. The labial biopsy is shown to be a further...

journal_title：Journal of clinical pathology

authors： Chisholm DM,Mason DK

更新日期：1968-09-01 00:00:00

abstract：:Three cases of plasmacytoma of the thyroid are described and their clinical and histological features recorded. Two were considered to be true extramedullary plasmacytomas, the third the initial manifestation of a disseminated myelomatous process. Plasmacytomas of the thyroid are shown to have many features in common ...

journal_title：Journal of clinical pathology

authors： More JR,Dawson DW,Ralston AJ,Craig I

更新日期：1968-09-01 00:00:00

abstract：:Painful lymphadenopathy developed in eight female patients after massive infusions of iron dextran for sideropaenic anaemia. Fever, arthralgias, and malaise were also features of the clinical picture. The histology of one lymph node is described and changes in it are discussed in relation to the pathogenesis of the sy...

journal_title：Journal of clinical pathology

authors： Theodoropoulos G,Makkous A,Constantoulakis M

更新日期：1968-07-01 00:00:00

abstract：:During a two-year period of observation Bacteroides species were isolated from specimens of pus and vaginal swabs from 115 patients in this hospital. Thirty-five representative strains proved on examination to be Bacteroides fragilis. Minimal inhibitory and minimal bactericidal concentrations of six antibiotics for th...

journal_title：Journal of clinical pathology

authors： Ingham HR,Selkon JB,Codd AA,Hale JH

更新日期：1968-07-01 00:00:00

abstract：:Platelet adhesiveness has been measured in citrated whole blood and in platelet-rich plasma obtained from normal subjects, splenectomized patients, and from patients in whom the diagnosis of recurrent venous thrombosis had been made. The duration of centrifugation used in the preparation of platelet-rich plasma was fo...

journal_title：Journal of clinical pathology

authors： McBride JA

更新日期：1968-05-01 00:00:00

abstract：:Components of the blood fibrinolytic system were measured in 43 patients with leukaemia. Increased fibrinolytic activity, indicated by a reduced plasma plasminogen level, was found in 14 patients. The combination of severe thrombocytopenia and increased fibrinolysis appeared to be a determinant in the production of a ...

journal_title：Journal of clinical pathology

authors： Ogston D,McAndrew GM,Ogston CM

更新日期：1968-03-01 00:00:00

abstract：:Current techniques for lymphocyte transformation are evaluated and criticised. A simple technique, designed to meet these criticisms, is described in detail, with particular reference to lymphocyte separation and scoring methods. ...

journal_title：Journal of clinical pathology

authors： Pentycross CR

更新日期：1968-03-01 00:00:00

abstract：:Care in the preparation and preservation of reagents, together with certain modifications in apparatus and technique, have eliminated the difficulties from plasma ammonia analysis. Ammonia contamination from the laboratory atmosphere has not proved an especial hazard, and no major setback has been encountered in the a...

journal_title：Journal of clinical pathology

authors： Fenton JC,Williams AH

更新日期：1968-01-01 00:00:00